Catalan COPD Ventilation Register (CatCoVeR)
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Dr. Joan Escarrabill (PRINCIPAL INVESTIGATOR)
Hospital Clínic / PDMAR /REDISSEC
Dra. Ana Córdoba
Hospital Universitari de Bellvitge
Dra. Ana Balañá
Hospital del Mar
Dra. Paola Carmona
Hospital Arnau de Vilanova
Dr. Antonio Antón
Hospital de la Santa Creu i Sant Pau
Dr. Manel Luján
Hospital Parc Taulí
Dra. Eva Farrero
Hospital de Bellvitge
Dra. Juana Martínez Llorens
Hospital del Mar
Dr. Sergi Martí
Hospital Vall d’Hebron
Dra. Cristina Embid
Hospital Clínic
Dra. Julia Tárrega
Hospital de Granollers
Dra. Mireia Espallargues
AQuAS / REDISSEC
Dr. Ramon Farré
Barcelona University / IDIBAPS / CIBERES
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[content_box icon=”bookmark-o” title=”Abstract”]
Chronic Obstructive Pulmonary Disease (COPD) is the fourth cause of death in the world. Several descriptive studies suggest that home mechanical ventilation (HMV) improves survival and quality of life of hypercapnic COPD patients. Randomized Controlled Trials (RCT) both are logistically complex and have well-known generalizability limitations. Despite the lack of conclusive evidence, the number of COPD patients on HMV is increasing in most countries. Thus, a different strategy is needed to assess the potential benefits of HMV.
This project hypothesizes that the multidisciplinary involvement of clinicians, healthcare authorities (through AQuAS), industry and patients will allow to gather comprehensive information of all stakeholders in a single database (“curated database of COPD patients on HMV”), with around 500 COPD patients in Catalonia, in order to: a) describe their clinical course (prospective observational study), b) find subgroups of patients (clusters) with shared characteristics and c) interrogate the curated database using a cohort multiple randomized controlled trial design (cmRCT), which allows the design of RCTs in specific subgroups of patients in whom complete information is available, so recruitment will be short and easy. The investigation of the potential benefits of high pressure ventilator settings would be a cmRCT prototype. Patient perspective will be considered since the beginning of the study. This novel research strategy will provide useful information for both patient care and design of health care services.
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