05. Introduction to Network Medicine

Edwin K. Silverman, M.D., Ph.D.
Channing Division of Network Medicine Pulmonary and Critical Care Medicine. Brigham and Women’s Hospital. Boston, Massachusetts

 

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Introduction to Network Medicine

 

Edwin K. Silverman, M.D., Ph.D.
Channing Division of Network Medicine Pulmonary and Critical Care Medicine. Brigham and Women’s Hospital. Boston, Massachusetts

 

The major respiratory diseases, including COPD, asthma, and idiopathic pulmonary fibrosis, are heterogeneous syndromes. Both clinical and machine learning approaches can be used to attempt to dissect disease heterogeneity. For example, cluster analysis of quantitative disease-related phenotypes has identified multiple potential subtypes of COPD. Genetic studies may help to understand disease heterogeneity and to define disease subtypes based on the underlying etiology of disease. However, studies to identify functional genetic variants and to investigate the biological mechanisms of these genes are necessary to provide comprehensive pathobiological insights.

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Dr. Edwin Silverman is a pulmonologist and genetic epidemiologist whose research focuses on the genetics of chronic obstructive pulmonary disease. He is the Principal Investigator of multiple studies of COPD genetics, including the Boston Early-Onset COPD Study, the Alpha 1-Antitrypsin Genetic Modifiers Study, the NETT Genetics Ancillary Study, and the Transcontinental COPD Genetics Study. He is also one of two Principal Investigators of the COPDGene Study. His recent work has focused on the identification of functional genetic variants influencing COPD susceptibility and on integrating imaging, physiology, clinical characterization, and genetics to identify COPD subtypes. He is a Professor of Medicine at Brigham and Women’s Hospital and Harvard Medical School, and he is the Chief of the Channing Division of Network Medicine at Brigham and Women’s Hospital.

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